Hallo,
hier ist eine interessante Studie vom letzten Jahr wo die Autoren nach Prädiktoren/Vorhersage-Variablen gesucht haben die, wenn sie verstärkt bei "noch" gesunden älteren Katzen auftreten, auf eine sich entwickelnde CNI schliessen lassen.
So könnte man einen Anhaltspunkt haben, welche Katzen besonders gefährdet sind eine CNI zu entwickeln.
Wenn ich mir die Entwicklung von Tillys Kreatininwert in den letzten Jahren ansehe, ist dieser stark angestiegen, obwohl der Wert noch im Referenzbereich war. (Urin wurde nie überprüft). Ein leicht erhöhter Kreatininwert wurde aber erst anfang dieses Jahres gemessen -- wie auch ein leicht erhöhter Harnstoff und ein USG, der die Diagnose verfestigte.
hier ist eine interessante Studie vom letzten Jahr wo die Autoren nach Prädiktoren/Vorhersage-Variablen gesucht haben die, wenn sie verstärkt bei "noch" gesunden älteren Katzen auftreten, auf eine sich entwickelnde CNI schliessen lassen.
So könnte man einen Anhaltspunkt haben, welche Katzen besonders gefährdet sind eine CNI zu entwickeln.
Evaluation of Predictors of the Development of Azotemia in Cats
R.E. Jepson, D. Brodbelt, C. Vallance, H.M. Syme, and J. Elliott
Background: Chronic kidney disease (CKD) is a common condition in geriatric cats. Diagnosis is based on the development of persistent azotemia with inadequate urine concentrating ability. Biomarkers are sought for early identification.
Hypothesis: Clinical variables, urine concentrating ability, proteinuria, and N-acetyl-b-D-glucosaminidase (NAG) index
will be predictive of cats at risk of developing azotemia within 12 months.
Animals: Client-owned nonazotemic geriatric (>=9 years) cats.
Methods: Prospective longitudinal cohort study monitoring a population of healthy nonazotemic geriatric cats every 6
months until development of azotemia, death, or the study end point (September 30, 2007). Multivariable logistic regression
analysis was used to assess baseline clinical, biochemical, and urinalysis variables, urine protein to creatinine ratio (UP/C), urine albumin to creatinine (UA/C) ratio, and urinary NAG index as predictors of development of azotemia.
Results: One hundred and eighteen cats were recruited with a median age of 13 years. Ninety-five cats (80.5%) had been
followed or reached the study end point by 12 months of which 30.5% (29/95) developed azotemia. Age, systolic blood pressure, plasma creatinine concentration, urine specific gravity, UP/C, UA/C, and NAG index were significantly associated with development of azotemia in the univariable analysis (P <= .05). However, in the multivariable analysis, only plasma creatinine concentration with either UP/C (Model 1) or UA/C (Model 2) remained significant.
Conclusions and Clinical Importance: This study demonstrates a high incidence of azotemia in a population of previously healthy geriatric cats. Proteinuria at presentation was significantly associated with development of azotemia although causal association cannot be inferred. Evaluation of NAG index offered no additional benefit.
Link: http://www.rvc.ac.uk/Research/News/documents/ElliottJonathan-Azotemia-JVIM_339.pdf
Die Ergebnisse waren, dass Proteinurie (UP/C wie auch UP/A) in Kombination mit Plasma Kreatinin signifikant Prädiktoren waren.R.E. Jepson, D. Brodbelt, C. Vallance, H.M. Syme, and J. Elliott
Background: Chronic kidney disease (CKD) is a common condition in geriatric cats. Diagnosis is based on the development of persistent azotemia with inadequate urine concentrating ability. Biomarkers are sought for early identification.
Hypothesis: Clinical variables, urine concentrating ability, proteinuria, and N-acetyl-b-D-glucosaminidase (NAG) index
will be predictive of cats at risk of developing azotemia within 12 months.
Animals: Client-owned nonazotemic geriatric (>=9 years) cats.
Methods: Prospective longitudinal cohort study monitoring a population of healthy nonazotemic geriatric cats every 6
months until development of azotemia, death, or the study end point (September 30, 2007). Multivariable logistic regression
analysis was used to assess baseline clinical, biochemical, and urinalysis variables, urine protein to creatinine ratio (UP/C), urine albumin to creatinine (UA/C) ratio, and urinary NAG index as predictors of development of azotemia.
Results: One hundred and eighteen cats were recruited with a median age of 13 years. Ninety-five cats (80.5%) had been
followed or reached the study end point by 12 months of which 30.5% (29/95) developed azotemia. Age, systolic blood pressure, plasma creatinine concentration, urine specific gravity, UP/C, UA/C, and NAG index were significantly associated with development of azotemia in the univariable analysis (P <= .05). However, in the multivariable analysis, only plasma creatinine concentration with either UP/C (Model 1) or UA/C (Model 2) remained significant.
Conclusions and Clinical Importance: This study demonstrates a high incidence of azotemia in a population of previously healthy geriatric cats. Proteinuria at presentation was significantly associated with development of azotemia although causal association cannot be inferred. Evaluation of NAG index offered no additional benefit.
Link: http://www.rvc.ac.uk/Research/News/documents/ElliottJonathan-Azotemia-JVIM_339.pdf
Wenn ich mir die Entwicklung von Tillys Kreatininwert in den letzten Jahren ansehe, ist dieser stark angestiegen, obwohl der Wert noch im Referenzbereich war. (Urin wurde nie überprüft). Ein leicht erhöhter Kreatininwert wurde aber erst anfang dieses Jahres gemessen -- wie auch ein leicht erhöhter Harnstoff und ein USG, der die Diagnose verfestigte.